Product Name: 3,4,5-Trimethoxybenzoic Acid Methyl Ester
Alias: Trimethoprim Impurity H
CASNo: 1916-07-0
Molecular Formula: C₁₁H₁₄O₅
Molecular Weight: 226.2259

Structural Formula:

Appearance: White monoclinic crystalline powder.
Storage: Store protected from light in a sealed container
Packaging: 25 kgs/drum
Capacity: 250 MT/year
Specification: Purity ≥99%
Application: Pharmaceutical intermediate, used in production of the anti-anxiety drug trimetazidine, the gastrointestinal drug trimebutine maleate, and other drugs

Applications of 3,4,5-Trimethoxybenzoic Acid Methyl Ester
I. Pharmaceutical Intermediate (Core Application)
It is a starting raw material for synthesizing various drugs and key intermediates, mainly used for:
Synthesis of antibacterial potentiator — Trimethoprim (TMP)
This is its primary application. It is a core intermediate for preparing trimethoprim, which is commonly combined with sulfonamide drugs (such as sulfamethoxazole) to make compound preparations like co-trimoxazole for treating respiratory, urinary tract and other bacterial infections, significantly enhancing antibacterial effects.
Synthesis of digestive system drug — Trimebutine Maleate
Used to synthesize trimebutine maleate, a commonly used gastrointestinal motility regulator for treating symptoms such as loss of appetite, nausea, vomiting, belching, diarrhea, constipation, and abdominal pain caused by gastrointestinal dysfunction.

Synthesis of anti-anxiety drug — Trimetazidine
Used as a raw material to synthesize trimetazidine, an anti-anxiety drug for relieving emotional tension, anxiety, insomnia and other mental symptoms.

Synthesis of other pharmaceutical intermediates
Through hydrolysis, hydrazinolysis, reduction and other reactions, a series of high-value intermediates such as 3,4,5-trimethoxybenzoic acid, 3,4,5-trimethoxybenzohydrazide, and 3,4,5-trimethoxybenzaldehyde can be derived, widely used in building other complex drug molecules.

II. Fine Chemicals and Materials Applications
Photosensitive dyes and UV absorbers
Used to synthesize UV absorbers in thermal recording materials, or as intermediates for photosensitive dyes, improving material photostability and color development performance.
Organic synthesis building block
With three methoxy groups and an ester group in its molecular structure and moderate reactivity, it is an ideal synthesis building block for constructing multi-substituted benzene ring compounds, used in preparing various functional chemicals, fragrance precursors, etc.